Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood.

ABSTRACT: Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early life promotes resilience to depression- and anxiety-like behaviors in adulthood. However, the role of PCMS in associated memory process is still unclear. In the present study, we found that adolescent PCMS facilitated extinction and inhibited fear response in reinstatement and spontaneous recovery tests in adult rats, and this effect was still present 1 week later. PCMS in adolescence increased the activity of brain-derived neurotrophic factor (BDNF)-extracellular signal-regulate

SUBMITTER: Deng JH 

PROVIDER: S-EPMC5552791 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature