Epigallocatechin-3-gallate inhibits H₂O₂-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.

ABSTRACT: Epigallocatechin-3-gallate (EGCG) is one of the major polyphenolic compounds present in green tea extracts and has been used as a potential drug for the treatment of numerous diseases. The present study aimed to elucidate the role and mechanism of EGCG in protecting against H₂O₂-induced apoptosis in mouse vascular smooth muscle cells (VSMCs). VSMCs were pretreated with various concentrations of EGCG for 2 hours prior to treatment with H₂O₂. Treatment with H₂O₂ significantly decreased the cell viability and induced apoptosis of VSMCs, which were attenuated by pretreatment with EGCG. In particular, EGCG pretreatment significantly inhibited the H₂O₂-induced upregulation of cleaved forms of caspase-3, caspa

SUBMITTER: Yan X 

PROVIDER: S-EPMC5552808 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature