The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease.

ABSTRACT:

Aims/hypothesis

The tryptophan metabolite kynurenine has potent immune modulatory and vasoactive properties. Experimental data implicate kynurenine in obesity-related morbidities. Epidemiological studies are, however, sparse. We evaluated associations of the plasma and urine kynurenine:tryptophan ratio (KTR) to incident type 2 diabetes.

Methods

We followed 2519 individuals with coronary artery disease (CAD; 73.1% men) without diabetes at baseline for a median of 7.6 years, during which 173 (6.9%) new incidences of type 2 diabetes were identified. Multivariate Cox regression analyses were applied to investigate the prospective relationships of plasma and urine KTR with new onset type 2 diabetes.

Results

At inclusion, mean (SD) age was 61.3 (10.4) years, BMI was 25.9 (3

SUBMITTER: Rebnord EW 

PROVIDER: S-EPMC5552838 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature