Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.

ABSTRACT: Control of phosphate metabolism is crucial to regulate aging in mammals. Klotho is a well-known anti-aging factor that regulates phosphate metabolism: mice mutant or deficient in Klotho exhibit phenotypes resembling human aging. Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) is required for Klotho expression under phosphate overload conditions. Loss-of-function Enpp1 ^ttw/ttw mice under phosphate overload conditions exhibited phenotypes resembling human aging and Klotho mutants, such as short life span, arteriosclerosis and osteoporosis, with elevated serum 1,25(OH)₂D₃ levels. Enpp1 ^ttw/ttw mice also exhibited significantly reduced renal Klotho expression under phosphate overload conditions, and aging phenotypes in th

SUBMITTER: Watanabe R 

PROVIDER: S-EPMC5552841 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature