A comprehensive phylogenetic analysis of copper transporting P_1B ATPases from bacteria of the Rhizobiales order uncovers multiplicity, diversity and novel taxonomic subtypes.

ABSTRACT: The ubiquitous cytoplasmic membrane copper transporting P_1B-1 and P_1B-3 -type ATPases pump out Cu⁺ and Cu²⁺ , respectively, to prevent cytoplasmic accumulation and avoid toxicity. The presence of five copies of Cu-ATPases in the symbiotic nitrogen-fixing bacteria Sinorhizobium meliloti is remarkable; it is the largest number of Cu⁺ -transporters in a bacterial genome reported to date. Since the prevalence of multiple Cu-ATPases in members of the Rhizobiales order is unknown, we performed an in silico analysis to understand the occurrence, diversity and evolution of Cu⁺ -ATPases in members of the Rhizobiales order. Multiple copies of Cu-ATPase coding genes (2-8) were detected in 45 of the 53 analyzed genomes. The diversity in

SUBMITTER: Cubillas C 

PROVIDER: S-EPMC5552934 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature