Amelogenin Affects Brushite Crystal Morphology and Promotes Its Phase Transformation to Monetite.

ABSTRACT: Amelogenin protein is involved in organized apatite crystallization during enamel formation. Brushite (CaHPO₄·2H₂O), one of the precursors of hydroxyapatite mineralization in vitro, has been used for fabrication of biomaterials for hard tissue repair. In order to explore its potential application in biomimetic material synthesis, we studied the influence of the enamel protein amelogenin on brushite morphology and phase transformation to monetite. Our results show that amelogenin can adsorb onto the surface of brushite, leading to the formation of layered morphology on the (010) face. Amelogenin promoted the phase transformation of brushite into monetite (CaHPO₄) in the dry state, presumably by interacting with crystalline water layers in brushite uni

SUBMITTER: Ren D 

PROVIDER: S-EPMC5553050 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature