Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Living Subjects.

ABSTRACT: Photoacoustic molecular imaging is an emerging and promising diagnostic tool for heavy metal ions detection. Methylmercury (MeHg⁺ ) is one of the most potent neurotoxins, which damages the brain and nervous system of human beings through fish consumption. The development of a selective and sensitive method for MeHg⁺ detection is highly desirable. In this Communication, we develope a chemoselective photoacoustic sensor (LP-hCy7) composed of the liposome (LP) and MeHg⁺ -responsive near-infrared (NIR) cyanine dye (hCy7) for MeHg⁺ detection within living subjects, such as zebrafish and mouse. The as-prepared LP-hCy7 nanoprobe displays unique dual-shift NIR absorbance peaks and produces a normalized turn-on response after the reaction of MeHg⁺

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5553071 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature