Presence of both A1 and A2a adenosine receptors in human cells and their interaction.

ABSTRACT: We have obtained pharmacological evidence for the expression of both A1- (inhibitory) and A2a- (stimulatory) adenosine receptors in cultured human foreskin fibroblasts and lung fibroblasts. The A1 receptors were sufficiently abundant in foreskin fibroblasts so that binding studies with a radioactively labeled specific ligand confirmed their existence. Both receptors were activated during the stimulation of cAMP accumulation and DNA synthesis by adenosine.

SUBMITTER: Ahmed AH 

PROVIDER: S-EPMC5553076 | biostudies-literature | 1995 Mar

REPOSITORIES: biostudies-literature