Intrasubtype B HIV-1 Superinfection Correlates with Delayed Neutralizing Antibody Response.

ABSTRACT: Understanding whether the neutralizing antibody (NAb) response impacts HIV-1 superinfection and how superinfection subsequently modulates the NAb response can help clarify correlates of protection from HIV exposures and better delineate pathways of NAb development. We examined associations between the development of NAb and the occurrence of superinfection in a well-characterized, antiretroviral therapy (ART)-naive, primary infection cohort of men who have sex with men. Deep sequencing was applied to blood plasma samples from the cohort to detect cases of superinfection. We compared the NAb activity against autologous and heterologous viruses between 10 participants with intrasubtype B superinfection and 19 monoinfected controls, matched to duration of infection and risk behavior. Three to

SUBMITTER: Wagner GA 

PROVIDER: S-EPMC5553187 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature