Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke.

ABSTRACT:

Objective

ST2 is a member of the toll-like receptor superfamily that can alter inflammatory signaling of helper T-cells. We investigated whether soluble ST2 (sST2) could independently predict outcome and hemorrhagic transformation (HT) in the setting of stroke.

Methods

We measured sST2 in patients enrolled in the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) network biomarker study. 646 patients had plasma samples collected at the time of hospital admission and 210 patients had a second sample collected 48 h after stroke onset. Functional outcome was assessed using the modified Rankin Scale (mRS), with good and poor outcomes defined as mRS 0-2 and 3-6, respectively. HT was classified using ECASS criteria. The relationships between sST2, outcome, an

SUBMITTER: Wolcott Z 

PROVIDER: S-EPMC5553222 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature