Extra-virgin olive oil ameliorates cognition and neuropathology of the 3xTg mice: role of autophagy.

ABSTRACT:

Objective

Consumption of extra virgin olive oil (EVOO), a major component of the Mediterranean diet, has been associated with reduced incidence of Alzheimer's disease (AD). However, the mechanisms involved in this protective action remain to be fully elucidated.

Methods

Herein, we investigated the effect of daily consumption of EVOO on the AD-like phenotype of a mouse mode of the disease with plaques and tangles.

Results

Triple transgenic mice (3xTg) received either regular chow or a chow diet supplemented with EVOO starting at 6 months of age for 6 months, then assessed for the effect of the diet on the AD-like neuropathology and behavioral changes. Compared with controls, mice receiving the EVOO-rich diet had an amelioration of their behavioral deficits, and a signi

SUBMITTER: Lauretti E 

PROVIDER: S-EPMC5553230 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature