Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective case-control study.

ABSTRACT:

Background

Gut bacteria might predispose to or protect from necrotising enterocolitis, a severe illness linked to prematurity. In this observational prospective study we aimed to assess whether one or more bacterial taxa in the gut differ between infants who subsequently develop necrotising enterocolitis (cases) and those who do not (controls).

Methods

We enrolled very low birthweight (1500 g and lower) infants in the primary cohort (St Louis Children's Hospital) between July 7, 2009, and Sept 16, 2013, and in the secondary cohorts (Kosair Children's Hospital and Children's Hospital at Oklahoma University) between Sept 12, 2011 and May 25, 2013. We prospectively collected and then froze stool samples for all infants. Cases were defined as infants whose clinical courses were

SUBMITTER: Warner BB 

PROVIDER: S-EPMC5553277 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature