The RNA-binding protein caper is required for sensory neuron development in Drosophila melanogaster.

ABSTRACT:

Background

Alternative splicing mediated by RNA-binding proteins (RBPs) is emerging as a fundamental mechanism for the regulation of gene expression. Alternative splicing has been shown to be a widespread phenomenon that facilitates the diversification of gene products in a tissue-specific manner. Although defects in alternative splicing are rooted in many neurological disorders, only a small fraction of splicing factors have been investigated in detail.

Results

We find that the splicing factor Caper is required for the development of multiple different mechanosensory neuron subtypes at multiple life stages in Drosophila melanogaster. Disruption of Caper function causes defects in dendrite morphogenesis of larval dendrite arborization neurons and neuronal positioning of embr

SUBMITTER: Olesnicky EC 

PROVIDER: S-EPMC5553308 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature