Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques.

ABSTRACT: The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although significant gene expression changes have been observed in the ARC during sexual maturation, it is unclear what changes occur during aging, especially in males. Therefore, in the present study, we profiled the expression of reproduction-related genes in the ARC of young and old male rhesus macaques, as well as old males that had received 6 months of hormone supplementation (HS) in the form of daily testosterone and dehydroepiandrosterone; we also compared morning vs night ARC gene expression in the old males. Using Affymetrix gene microarrays, we found little evi

SUBMITTER: Eghlidi DH 

PROVIDER: S-EPMC5553588 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature