The analysis of APOL1 genetic variation and haplotype diversity provided by 1000 Genomes project.

ABSTRACT:

Background

The APOL1 gene variants has been shown to be associated with an increased risk of multiple kinds of diseases, particularly in African Americans, but not in Caucasians and Asians. In this study, we explored the single nucleotide polymorphism (SNP) and haplotype diversity of APOL1 gene in different races provided by 1000 Genomes project.

Methods

Variants of APOL1 gene in 1000 Genome Project were obtained and SNPs located in the regulatory region or coding region were selected for genetic variation analysis. Total 2504 individuals from 26 populations were classified as four groups that included Africa, Europe, Asia and Admixed populations. Tag SNPs were selected to evaluate the haplotype diversities in the four populations by HaploStats software.

Results

APOL1

SUBMITTER: Peng T 

PROVIDER: S-EPMC5553676 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature