Gastrointestinal Features of Chronic Granulomatous Disease Found During Endoscopy.

ABSTRACT:

Background & aims

Chronic granulomatous disease (CGD) is an inherited disorder of the reduced nicotinamide adenine dinucleotide phosphate oxidase complex within phagocytic cells that predisposes people to bacterial and fungal infections. Approximately 40% of patients with CGD have gastrointestinal involvement. We aimed to characterize the endoscopic features of gastrointestinal CGD and define the role of endoscopy in patients.

Methods

We created a database of all patients with CGD seen at the National Institutes of Health from 1990 through 2010. We identified patients who had an endoscopy, and collected information from those with CGD-associated inflammatory bowel disease. We analyzed clinical data (demographic information and symptoms), endoscopic data (indication, preparat

SUBMITTER: Khangura SK 

PROVIDER: S-EPMC5553864 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature