Variability in quantitative analysis of atherosclerotic plaque inflammation using 18F-FDG PET/CT.

ABSTRACT:

Background

18F-FDG-PET(/CT) is increasingly used in studies aiming at quantifying atherosclerotic plaque inflammation. Considerable methodological variability exists. The effect of data acquisition and image analysis parameters on quantitative uptake measures, such as standardized uptake value (SUV) and target-to-background ratio (TBR) has not been investigated extensively.

Objective

The goal of this study was to explore the effect of several data acquisition and image analysis parameters on quantification of vascular wall 18F-FDG uptake measures, in order to increase awareness of potential variability.

Methods

Three whole-body emission scans and a low-dose CT scan were acquired 38, 60 and 90 minutes after injection of 18F-FDG in six rheumatoid arthritis patients with

SUBMITTER: Lensen KDF 

PROVIDER: S-EPMC5553940 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature