Hepatosplenic Candidiasis Without Prior Documented Candidemia: An Underrecognized Diagnosis?

ABSTRACT:

Introduction

Patients with a history of chemotherapy or stem cell transplantation (SCT) and prolonged neutropenia are at risk for hepatic and/or splenic seeding of Candida. In our experience, hepatosplenic candidiasis (HSC) without documented candidemia often remains unrecognized.

Case presentations

We describe three cases of HSC without documented candidemia and the challenges in establishing the diagnosis and adequately treating this condition. The first patient had a history of SCT for treatment of breast cancer and was scheduled for hemihepatectomy for suspected liver metastasis. A second opinion at our institute resulted in the diagnosis of hepatic candidiasis without prior documented candidemia, for which she was treated successfully with fluconazole. The second

SUBMITTER: van Prehn J 

PROVIDER: S-EPMC5553951 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature