Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease.

ABSTRACT:

Introduction

Findings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits.

Methods

We evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators.

Results

LOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonfer

SUBMITTER: Fardo DW 

PROVIDER: S-EPMC5554082 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature