Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.

ABSTRACT: Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes (CT/ MR), recruitment of immune cells (¹¹¹In-WBC SPECT), or enhanced glycolytic flux seen in inflammatory cells (¹⁸F-FDG PET). However, these strategies are often inadequate to detect bacterial infection and are not specific for living bacteria. Recent approaches have taken advantage of key metabolic differences between prokaryotic and eukaryotic organisms, allowing easier distinction between bacteria and their host. In this report, we exploited one key difference, bacterial cell wall biosynthesis, to detect living ba

SUBMITTER: Neumann KD 

PROVIDER: S-EPMC5554133 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature