Rhodoterpenoids A?C, Three New Rearranged Triterpenoids from Rhododendron latoucheae by HPLC?MS?SPE?NMR.

ABSTRACT: Rhodoterpenoids A?C (1?3), three new rearranged triterpenoids, together with one new biogenetically related compound, rhodoterpenoid D (4), were isolated and efficiently elucidated from Rhododendron latoucheae by high-performance liquid chromatography-mass spectrometry-solid-phase extraction-nuclear magnetic resonance (HPLC?MS?SPE?NMR). Compounds 1 and 2 possess an unprecedented skeleton with a 5/7/6/6/6-fused pentacyclic ring system, while compound 3 contains a unique 6/7/6/6/6-fused pentacyclic carbon backbone. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Plausible biogenetic pathways for 1?4 were proposed. Compounds 1 and 4 showed potential activity against herpes simplex virus 1 (HSV-1) with IC50 values of 8.62 and 6.87??M, respectively.

SUBMITTER: Liu F 

PROVIDER: S-EPMC5554136 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature