Plasma GDF15 level is elevated in psychosis and inversely correlated with severity.

ABSTRACT: Accumulating evidence suggests that GDF15 is a biomarker for ageing and morbidity of many somatic disorders such as cancer and inflammatory disorders. Recently, elevated serum GDF15 level was proposed as a marker for mood disorder. However, psychosis severity was not investigated in relation to plasma GDF15 levels. In the present study we measured GDF15 levels in plasma of 120 psychosis patients compared to 120 age and gender matched healthy controls. Within the patient cohort GDF15 levels were evaluated for association with age, gender, lifestyle factors, C-reactive protein levels, psychosis severity and metabolic disorder. Psychosis patients had elevated GDF15 levels compared to controls (median_Psychosis = 744 ng/mL, median_controls = 516 ng/mL, p < 0.001). Within th

SUBMITTER: Kumar P 

PROVIDER: S-EPMC5554200 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature