Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica.

ABSTRACT: Complex phenotypes, such as lipid accumulation, result from cooperativity between regulators and the integration of multiscale information. However, the elucidation of such regulatory programs by experimental approaches may be challenging, particularly in context-specific conditions. In particular, we know very little about the regulators of lipid accumulation in the oleaginous yeast of industrial interest Yarrowia lipolytica. This lack of knowledge limits the development of this yeast as an industrial platform, due to the time-consuming and costly laboratory efforts required to design strains with the desired phenotypes. In this study, we aimed to identify context-specific regulators and mechanisms, to guide explorations of the regulation of lipid accumulation in Y. lipolytica</

SUBMITTER: Trebulle P 

PROVIDER: S-EPMC5554221 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature