Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH.

ABSTRACT: Gliomas maintain an acidic extracellular pH (pH_e), which promotes tumor growth and builds resistance to therapy. Given evidence that acidic pH_e beyond the tumor core indicates infiltration, we hypothesized that imaging the intratumoral pH_e in relation to the peritumoral pH_e can provide a novel readout of therapeutic influence on the tumor microenvironment. We used Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), which utilizes chemical shifts of non-exchangeable protons from macrocyclic chelates (e.g., DOTP^8-) complexed with paramagnetic thulium (Tm³⁺), to generate pH_e maps in rat brains bearing U251 tumors. Following TmDOTP^5- infusion, T₂-weighted MRI provided delineation of the t

SUBMITTER: Rao JU 

PROVIDER: S-EPMC5554228 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature