Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study.

ABSTRACT:

Purpose

When postoperative ileus is not resolved after 5 days or recurs after resolution, prolonged POI (PPOI) is diagnosed. PPOI increases discomfort, morbidity and hospitalisation length, and is mainly caused by an inflammatory response following intestinal manipulation. This response can be weakened by targeting the cholinergic anti-inflammatory pathway, with nicotine as essential regulator. Chewing gum, already known to stimulate gastrointestinal motility itself, combined with nicotine is hypothesised to improve gastrointestinal recovery and prevent PPOI. This pilot study is the first to assess efficacy and safety of nicotine gum in colorectal surgery.

Methods

Patients undergoing elective oncological colorectal surgery were enrolled in this double-blind, parallel-group,

SUBMITTER: Lambrichts DPV 

PROVIDER: S-EPMC5554272 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature