CK2 is a key regulator of SLC4A2-mediated Cl^-/HCO₃^- exchange in human airway epithelia.

ABSTRACT: Transepithelial bicarbonate secretion by human airway submucosal glands and surface epithelial cells is crucial to maintain the pH-sensitive innate defence mechanisms of the lung. cAMP agonists stimulate HCO₃^- secretion via coordinated increases in basolateral HCO₃^- influx and accumulation, as well as CFTR-dependent HCO₃^- efflux at the luminal membrane of airway epithelial cells. Here, we investigated the regulation of a basolateral located, DIDS-sensitive, Cl^-/HCO₃^- exchanger, anion exchanger 2 (AE2; SLC4A2) which is postulated to act as an acid loader, and therefore potential regulator of HCO₃^- secretion, in human airway epithelial cells. Using intracellular pH measure

SUBMITTER: Ibrahim SH 

PROVIDER: S-EPMC5554290 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature