Current concepts in bone metastasis, contemporary therapeutic strategies and ongoing clinical trials.

ABSTRACT:

Background

Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the rapid rate of progress in both the basic science literature and therapies undergoing clinical trials makes staying abreast with current developments challenging. This review seeks to provide an update on the current state of the science in bone metastasis research and give a snap shot of therapies in clinical trials for bone metastatic cancer.

Main body

Bone metastasis represents a difficult to treat clinical scenario due to pain, increased fracture risk, decreased quality of life and diminished overall survival outcomes. Multiple types of cancer have the sp

SUBMITTER: Gdowski AS 

PROVIDER: S-EPMC5554406 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature