Cortico-amygdalar maturational coupling is associated with depressive symptom trajectories during adolescence.

ABSTRACT:

Background

Adolescence is characterized by increasing prevalence of depressive symptomatology, along with significant structural brain development. While much research has examined focal abnormalities in gray matter structure underlying depression, we employed a structural coupling approach to examine whether longitudinal associations between amygdala and cortical development (referred to as maturational coupling) was related to concurrent changes in depressive symptomatology during adolescence.

Method

166 participants underwent up to three MRI scans (367 scans) between 11 and 20 years of age. Depressive symptoms were measured at three coinciding time points using the Center for Epidemiological Studies-Depression scale. Linear mixed models were employed to identify whether c

SUBMITTER: Vijayakumar N 

PROVIDER: S-EPMC5554433 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature