Cis-Regulatory Divergence in Gene Expression between Two Thermally Divergent Yeast Species.

ABSTRACT: Gene regulation is a ubiquitous mechanism by which organisms respond to their environment. While organisms are often found to be adapted to the environments they experience, the role of gene regulation in environmental adaptation is not often known. In this study, we examine divergence in cis-regulatory effects between two Saccharomycesspecies, S. cerevisiaeand S. uvarum, that have substantially diverged in their thermal growth profile. We measured allele specific expression (ASE) in the species' hybrid at three temperatures, the highest of which is lethal to S. uvarumbut not the hybrid or S. cerevisiae. We find that S. uvarumalleles can be expressed at the same level as S. cerevisiaealleles at high temperature and most cis-acting differences in gene expression are not dependent on tempera

SUBMITTER: Li XC 

PROVIDER: S-EPMC5554586 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature