Hyperpolarized ¹³C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1T.

ABSTRACT: The expected signal in echo-planar spectroscopic imaging experiments was explicitly modeled jointly in spatial and spectral dimensions. Using this as a basis, absorptive-mode type detection can be achieved by appropriate choice of spectral delays and post-processing techniques. We discuss the effects of gradient imperfections and demonstrate the implementation of this sequence at low field (1.05T), with application to hyperpolarized [1-¹³C] pyruvate imaging of the mouse brain. The sequence achieves sufficient signal-to-noise to monitor the conversion of hyperpolarized [1-¹³C] pyruvate to lactate in the mouse brain. Hyperpolarized pyruvate imaging of mouse brain metabolism using an absorptive-mode EPSI sequence can be applied to more sophisticated murine disease and tr

SUBMITTER: Miloushev VZ 

PROVIDER: S-EPMC5554620 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature