Development of a New Folate-Derived Ga-68-Based PET Imaging Agent.

ABSTRACT:

Purpose

The folate receptor (FR) has emerged as an interesting diagnostic and therapeutic drug target with many potential applications in oncologic and inflammatory disorders. It was therefore the aim of this study to develop a folate-derived Ga-68-based positron emission tomography (PET) imaging tracer that is straightforward to radiolabel and could be broadly used in clinical studies. We validated its target binding affinity and specificity and compared it to [^99mTc]EC20, the folate single-photon emission computed tomography (SPECT) imaging tracer that has been most extensively studied clinically so far.

Procedures

The new folic acid-derived PET imaging agent is linked via a polyethyleneglycol linker to the chelator 1,4,7-triazacyclononane-1,4,7-trisacetic acid

SUBMITTER: Brand C 

PROVIDER: S-EPMC5554734 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature