A population level atlas of Mus musculus craniofacial skeleton and automated image-based shape analysis.

ABSTRACT: Laboratory mice are staples for evo/devo and genetics studies. Inbred strains provide a uniform genetic background to manipulate and understand gene-environment interactions, while their crosses have been instrumental in studies of genetic architecture, integration and modularity, and mapping of complex biological traits. Recently, there have been multiple large-scale studies of laboratory mice to further our understanding of the developmental basis, evolution, and genetic control of shape variation in the craniofacial skeleton (i.e. skull and mandible). These experiments typically use micro-computed tomography (micro-CT) to capture the craniofacial phenotype in 3D and rely on manually annotated anatomical landmarks to conduct statistical shape analysis. Although the common choice for imag

SUBMITTER: Maga AM 

PROVIDER: S-EPMC5554826 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature