Parametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease.

ABSTRACT:

Background

In the search for specific phenotypes of chronic obstructive pulmonary disease (COPD) computed tomography (CT) derived Parametric Response Mapping (PRM) has been introduced. This study evaluates the association between PRM and currently available biomarkers of disease severity in COPD.

Methods

Smokers with and without COPD were characterized based on questionnaires, pulmonary function tests, body plethysmography, and low-dose chest CT scanning. PRM was used to calculate the amount of emphysema (PRM^Emph) and non-emphysematous air trapping (i.e. functional small airway disease, PRM^fSAD). PRM was first compared with other biomarkers for emphysema (Perc15) and air trapping (E/I-ratio_MLD). Consequently, linear regression models were uti

SUBMITTER: Pompe E 

PROVIDER: S-EPMC5555031 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature