Focusing light inside dynamic scattering media with millisecond digital optical phase conjugation.

ABSTRACT: Wavefront shaping based on digital optical phase conjugation (DOPC) focuses light through or inside scattering media, but the low speed of DOPC prevents it from being applied to thick, living biological tissue. Although a fast DOPC approach was recently developed, the reported single-shot wavefront measurement method does not work when the goal is to focus light inside, instead of through, highly scattering media. Here, using a ferroelectric liquid crystal based spatial light modulator, we develop a simpler but faster DOPC system that focuses light not only through, but also inside scattering media. By controlling 2.6 × 10⁵ optical degrees of freedom, our system focused light through 3 mm thick moving chicken tissue, with a system latency of 3.0 ms. Using ultrasound-guided DOPC,

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5555171 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature