Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b₅/Cytochrome b₅ Reductase/NADH System.

ABSTRACT: Cytoglobin is a heme-containing protein ubiquitous in mammalian tissues. Unlike the evolutionarily related proteins hemoglobin and myoglobin, cytoglobin shows a six-coordinated heme binding, with the heme iron coordinated by two histidine side chains. Cytoglobin is involved in cytoprotection pathways through yet undefined mechanisms, and it has recently been demonstrated that cytoglobin has redox signaling properties via nitric oxide (NO) and nitrite metabolism. The reduced, ferrous cytoglobin can bind oxygen and will react with NO in a dioxygenation reaction to form nitrate, which dampens NO signaling. When deoxygenated, cytoglobin can bind nitrite and reduce it to NO. This oxidoreductase activity could be catalytic if an effective reduction system exists to regenerate the reduced heme sp

SUBMITTER: Amdahl MB 

PROVIDER: S-EPMC5555378 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature