Association between serrated epithelial changes and colorectal dysplasia in inflammatory bowel disease.

ABSTRACT:

Background and aims

Serrated epithelial change (SEC) is a histologic finding in longstanding colitis that may be associated with dysplasia. Our primary aim was to determine the incidence of dysplasia and colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients with SEC. Secondary aims were to determine the rate of location concordance between SEC and dysplasia/CRC and to identify other risk factors associated with dysplasia in IBD patients with SEC.

Methods

A retrospective, descriptive, observational study was performed by searching the Pathology Data System at a single tertiary referral center for a histologic finding of "serrated epithelial change." The patient's first pathology specimen with SEC was designated the index SEC. All subsequent pathology reports we

SUBMITTER: Parian A 

PROVIDER: S-EPMC5555397 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature