An RNA Recognition Motif-Containing Protein Functions in Meiotic Silencing by Unpaired DNA.

ABSTRACT: Meiotic silencing by unpaired DNA (MSUD) is a biological process that searches pairs of homologous chromosomes (homologs) for segments of DNA that are unpaired. Genes found within unpaired segments are silenced for the duration of meiosis. In this report, we describe the identification and characterization of Neurospora crassa sad-7, a gene that encodes a protein with an RNA recognition motif (RRM). Orthologs of sad-7 are found in a wide range of ascomycete fungi. In N. crassa, sad-7 is required for a fully efficient MSUD response to unpaired genes. Additionally, at least one parent must have a functional sad-7 allele for a cross to produce ascospores. Although sad-7-null crosses are barren, sad-7^Δ strains grow at a wild-type (wt)

SUBMITTER: Samarajeewa DA 

PROVIDER: S-EPMC5555490 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature