Lymph node status have a prognostic impact in breast cancer patients with distant metastasis.

ABSTRACT:

Background

The objective of this retrospective study was to determine whether lymph node metastasis has a prognostic impact on patients with stage IV breast cancer.

Patients and methods

Seven thousand three hundred and seventy-nine patients with de novo stage IV breast cancer diagnosed from 2004 to 2013 were identified. Kaplan-Meier estimate method was fitted to measure overall survival and breast cancer-specific survival (BCSS). Cox proportional hazard analysis was used to evaluate the association between N stage and BCSS after controlling variables such as other patient/tumor characteristics.

Results

The primary site of M1 tumors was mainly upper-outer quadrant and overlapping lesion of the breast. Patients with N1 disease had better overall survival and BCSS than d

SUBMITTER: Tang C 

PROVIDER: S-EPMC5555564 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature