The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia.

ABSTRACT:

Background

Recent studies have suggested that non-definitive patterns on high-resolution CT (HRCT) scan provide sufficient diagnostic specificity to forgo surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis (IPF). The objective of this study was to determine test characteristics of non-definitive HRCT patterns for identifying histopathological usual interstitial pneumonia (UIP).

Methods

Patients with biopsy-proven interstitial lung disease (ILD) and non-definitive HRCT scans were identified from two academic ILD centres. Test characteristics for HRCT patterns as predictors of UIP on surgical lung biopsy were derived and validated in independent cohorts.

Results

In the derivation cohort, 64/385 (17%) had possible UIP pattern on HRCT; 321/385 (83%) ha

SUBMITTER: Brownell R 

PROVIDER: S-EPMC5555580 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature