Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme.

ABSTRACT: C-H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of methods for C-H functionalization promises to transform the way synthetic chemistry is performed. The intermolecular amination of C-H bonds represents a particularly desirable and challenging transformation for which no efficient, highly selective, and renewable catalysts exist. Here we report the directed evolution of an iron-containing enzymatic catalyst-based on a cytochrome P450 monooxygenase-for the highly enantioselective intermolecular amination of benzylic C-H bonds. The biocatalyst is capable of up to 1,300 turnovers, exhibits excellent enantioselectivities, and provides access to valuable benzylic amines. Iron complexes are

SUBMITTER: Prier CK 

PROVIDER: S-EPMC5555633 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature