A comprehensive study of smoking-specific microRNA alterations in head and neck squamous cell carcinoma.

ABSTRACT:

Objective

While tobacco smoking is a well-known risk factor for head and neck squamous cell carcinoma (HNSCC), the molecular mechanisms underlying tobacco-induced HNSCC remain unclear. This study sought to comprehensively identify microRNA (miRNA) alterations and evaluate their clinical relevance in smoking-induced HNSCC pathogenesis and progression.

Materials and methods

Using small RNA-sequencing data and clinical data from 145 HNSCC patients, we performed a series of differential expression and correlation analyses to identify a panel of tobacco-dysregulated miRNAs associated with key clinical characteristics in HNSCC. We then examined the expression patterns of these miRNAs in normal epithelial cell lines following exposure to cigarette smoke extract.

Results

Our

SUBMITTER: Krishnan AR 

PROVIDER: S-EPMC5555648 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature