Dengue subgenomic flaviviral RNA disrupts immunity in mosquito salivary glands to increase virus transmission.

ABSTRACT: Globally re-emerging dengue viruses are transmitted from human-to-human by Aedes mosquitoes. While viral determinants of human pathogenicity have been defined, there is a lack of knowledge of how dengue viruses influence mosquito transmission. Identification of viral determinants of transmission can help identify isolates with high epidemiological potential. Additionally, mechanistic understanding of transmission will lead to better understanding of how dengue viruses harness evolution to cycle between the two hosts. Here, we identified viral determinants of transmission and characterized mechanisms that enhance production of infectious saliva by inhibiting immunity specifically in salivary glands. Combining oral infection of Aedes aegypti mosquitoes and reverse genetics, we identified two

SUBMITTER: Pompon J 

PROVIDER: S-EPMC5555716 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature