Association Between Vascular Pathology and Rate of Cognitive Decline Independent of Alzheimer's Disease Pathology.

ABSTRACT:

Objectives

To examine the association between vascular pathology and rate of cognitive decline in older adults independent of Alzheimer's disease (AD) pathology.

Design

Prospective cohort study.

Setting

Community sample.

Participants

Individuals from the Einstein Aging Study autopsy series (N = 62).

Measurements

The Blessed Information-Memory-Concentration (BIMC) test was used to assess global cognitive status. AD pathology was quantified according to Braak stage (<3 vs ≥ 3). Vascular pathology was quantified using a previously reported macrovascular lesion (MVL) score. The association between vascular pathology and antemortem rates of cognitive decline adjusted for level of AD pathology was assessed using linear mixed-effects models.

Results

Mean

SUBMITTER: Ezzati A 

PROVIDER: S-EPMC5555777 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature