Do antiepileptic drugs increase the risk of infectious diseases? A meta-analysis of placebo-controlled studies.

ABSTRACT:

Aims

Experimental studies show that some antiepileptic drugs (AEDs) may modify natural immune defences, thus influencing the risk of developing infectious diseases. The aim of this meta-analysis was to explore whether AEDs as a class of drugs or singularly may increase risk of infectious diseases.

Methods

A meta-analysis of all randomized, double-blind, placebo-controlled trials (RCTs) investigating any AED in any condition was performed. All terms that could be coded in the System Organ Classes (SOCs) of infections and infestations using the Medical Dictionary for Regulatory Activities were recorded. Additional subanalyses were performed also pooling together AEDs sharing similar mechanisms of action.

Results

Two hundreds and sixty-nine double-blind, placebo-controll

SUBMITTER: Zaccara G 

PROVIDER: S-EPMC5555858 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature