CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6⁺ cells in an experimental suction blister.

ABSTRACT:

Aims

GSK3050002, a humanized IgG1κ antibody with high binding affinity to human CCL20, was administered in a first-in-human study to evaluate safety, pharmacokinetics (PK) and pharmacodynamics (PD). An experimental skin suction blister model was employed to assess target engagement and the ability of the compound to inhibit recruitment of inflammatory CCR6 expressing cells.

Methods

This study was a randomized, double-blind (sponsor open), placebo-controlled, single-centre, single ascending intravenous dose escalation trial in 48 healthy male volunteers.

Results

GSK3050002 (0.1-20 mg kg^-1 ) was well tolerated and no safety concerns were identified. The PK was linear over the dose range, with a half-life of approximately 2 weeks. Complex of GSK3050002/CCL20 i

SUBMITTER: Bouma G 

PROVIDER: S-EPMC5555862 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature