Individualising the dose of allopurinol in patients with gout.

ABSTRACT:

Aims

The aims of the study were to: 1) determine if a plasma oxypurinol concentration-response relationship or an allopurinol dose-response relationship best predicts the dose requirements of allopurinol in the treatment of gout; and 2) to construct a nomogram for calculating the optimum maintenance dose of allopurinol to achieve target serum urate (SU) concentrations.

Methods

A nonlinear regression analysis was used to examine the plasma oxypurinol concentration- and allopurinol dose-response relationships with serum urate. In 81 patients (205 samples), creatinine clearance (CL_CR ), concomitant diuretic use and SU concentrations before (U_P ) and during (U_T ) treatment were monitored across a range of allopurinol doses (D, 50-700 mg daily). P

SUBMITTER: Kannangara DRW 

PROVIDER: S-EPMC5555877 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature