Bayesian estimation of physiological parameters governing a dynamic two-compartment model of exhaled nitric oxide.

ABSTRACT: The fractional concentration of nitric oxide in exhaled breath (feNO) is a biomarker of airway inflammation with applications in clinical asthma management and environmental epidemiology. feNO concentration depends on the expiratory flow rate. Standard feNO is assessed at 50 mL/sec, but "extended NO analysis" uses feNO measured at multiple different flow rates to estimate parameters quantifying proximal and distal sources of NO in the lower respiratory tract. Most approaches to modeling multiple flow feNO assume the concentration of NO throughout the airway has achieved a "steady-state." In practice, this assumption demands that subjects maintain sustained flow rate exhalations, during which both feNO and expiratory flow rate must remain constant, and the feNO maneuver is summarized by the

SUBMITTER: Muchmore P 

PROVIDER: S-EPMC5555880 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature