MicroRNA-214 modulates neural progenitor cell differentiation by targeting Quaking during cerebral cortex development.

ABSTRACT: The accurate generation of an appropriate number of different neuronal and glial subtypes is fundamental to normal brain functions and requires tightly orchestrated spatial and temporal developmental programmes to maintain the balance between the proliferation and the differentiation of neural progenitor cells. However, the molecular mechanism governing this process has not been fully elucidated. Here, we found that miR-214-3p was highly expressed in neural progenitor cells and dynamically regulated during neocortical development. Moreover, our in vivo and in vitro studies showed that miR-214 inhibited self-renewal of neural progenitor cells and promoted neurogenesis. In addition, after target screening, we identified miR-214 targets including Quaking (Qki) by binding the 3'- untranslated

SUBMITTER: Shu P 

PROVIDER: S-EPMC5556025 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature