Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study.

ABSTRACT:

Objectives

To investigate whether there is evidence that an increasing proportion of HIV infected patients is starting to experience increases in viral load and decreases in CD4 cell count that are consistent with exhaustion of available treatment options.

Design

Multicentre cohort study.

Setting

Six large HIV treatment centres in southeast England.

Participants

All individuals seen for care between 1 January 1996 and 31 December 2002.

Main outcome measures

Exposure to individual antiretroviral drugs and drug classes, CD4 count, plasma HIV RNA burden.

Results

Information is available on 16,593 individuals (13,378 (80.6%) male patients, 10,340 (62.3%) infected via homosexual or bisexual sex, 4426 (26.7%) infected via heterosexual sex, median age 34

SUBMITTER: Sabin CA 

PROVIDER: S-EPMC555628 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature