High resolution measurement of DUF1220 domain copy number from whole genome sequence data.

ABSTRACT:

Background

DUF1220 protein domains found primarily in Neuroblastoma BreakPoint Family (NBPF) genes show the greatest human lineage-specific increase in copy number of any coding region in the genome. There are 302 haploid copies of DUF1220 in hg38 (~160 of which are human-specific) and the majority of these can be divided into 6 different subtypes (referred to as clades). Copy number changes of specific DUF1220 clades have been associated in a dose-dependent manner with brain size variation (both evolutionarily and within the human population), cognitive aptitude, autism severity, and schizophrenia severity. However, no published methods can directly measure copies of DUF1220 with high accuracy and no method can distinguish between domains within a clade.

Results

Here we des

SUBMITTER: Astling DP 

PROVIDER: S-EPMC5556342 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature